Para Nitrobenzamide
4-Nitrobenzamide (p-Nitrobenzamide) · CAS 619-80-7
Para Nitrobenzamide is a versatile building block at the crossroads of pharmaceutical and dye chemistry. Reduced to 4-aminobenzamide, it feeds into sulfonamide drug synthesis and azo dye manufacture. Chelora Dyes supplies it lot-tested with batch data and a Safety Data Sheet on every shipment, so the intermediate you qualified at trial is the intermediate you receive on every order.
Also sold as: 4-Nitrobenzamide · p-Nitrobenzamide · 4-Nitrobenzoic acid amide · Benzamide, 4-nitro-
- CAS number
- 619-80-7
- Molecular formula
- C7H6N2O3
- Molecular weight
- 166.13 g/mol
- Appearance
- White to pale yellow crystalline powder
Structure of Para Nitrobenzamide
Benzene ring with amide and nitro groupsWhat Para Nitrobenzamide is
A nitro-substituted benzamide that serves as a pivotal intermediate in both pharmaceutical and dye manufacturing. The nitro group at the para position is readily reduced to the corresponding amine, unlocking routes to sulfonamide antibiotics, azo dyes and agrochemical actives.
Identification
Use these details when you match Para Nitrobenzamide against your own purchase specification.
- Product name
- Para Nitrobenzamide
- Chemical name
- 4-Nitrobenzamide (p-Nitrobenzamide)
- CAS number
- 619-80-7
- Molecular formula
- C7H6N2O3
- Molecular weight
- 166.13 g/mol
- Product family
- Pharmaceutical and dye intermediates
- Common end use
- Pharmaceutical APIs, sulfonamide drugs, azo dyes, agrochemicals
Physical and chemical behaviour
The points that decide how the material handles on your plant.
- Appearance
- White to pale yellow crystalline powder. Colour may deepen slightly on prolonged storage or light exposure.
- Melting point
- 199–201 °C. A sharp melting range indicates high purity.
- Solubility
- Slightly soluble in water. Soluble in hot ethanol, DMSO and dilute alkali. The limited water solubility means the material is typically dissolved in an organic solvent or warm alkaline solution for downstream reactions.
- Reactivity
- The nitro group undergoes catalytic hydrogenation or chemical reduction (iron/HCl, tin/HCl, sodium dithionite) to give 4-aminobenzamide. The amide group is hydrolytically stable under mild conditions.
- Stability
- Stable under normal storage conditions when kept dry and protected from light. No special atmosphere required.
- Incompatibilities
- Strong reducing agents (uncontrolled reduction), strong bases at high temperature (amide hydrolysis), strong oxidisers.
Typical specification
Every lot is tested in-house against its specification before dispatch, and the results travel with the shipment. If you work to a tighter window on any line below, send it to us and we will confirm whether we can supply to it.
| Parameter | Indicative value | Why it matters to you |
|---|---|---|
| Appearance | White to pale yellow powder | Consistent colour confirms the batch has not degraded or been contaminated during storage or transit. |
| Assay (purity) | 99.0% minby HPLC | Sets the active content for downstream reactions. A lower assay means lower yield and potential impurity carry-through into the pharmaceutical or dye product. |
| Melting point | 199–201 °C | A sharp melting range confirms identity and purity. A depressed or broad range indicates contamination. |
| Moisture | 0.5% max | Affects weighing accuracy and reaction stoichiometry. Excess moisture can also cause caking during storage. |
| Residue on ignition | 0.1% max | Indicates inorganic impurities that may interfere with catalytic hydrogenation or carry through to the final product. |
| Related substances | Controlledreported on batch report | Isomeric nitrobenzamides and hydrolysis products (4-nitrobenzoic acid) affect downstream purity, especially in pharmaceutical applications. |
| Clarity of solution | Clear | A hazy solution in DMSO or warm ethanol indicates insoluble impurities that will interfere with homogeneous reactions. |
| Particle size | Free-flowing powder | Governs dissolution rate and uniformity of the reduction reaction when the material is charged to the reactor. |
Working to a pharmaceutical grade? Send us your purchase specification, including assay, moisture, residue on ignition and any impurity limits, through the contact page. We will confirm what we can supply, and send a sample with its test data so you can run it against your current material.
Where Para Nitrobenzamide sits on the synthesis route
Para Nitrobenzamide is made from benzoic acid through nitration and amidation, and is then reduced to 4-aminobenzamide for use in drug and dye synthesis. Understanding the steps either side of it explains why purity, melting point and residual acid content are the lines buyers watch.
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Benzoic acid
The starting material. Nitrated with mixed acid (HNO3/H2SO4) to introduce a nitro group at the para position, yielding 4-nitrobenzoic acid.
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4-Nitrobenzoic acid
The carboxylic acid intermediate. Converted to the acid chloride with thionyl chloride (SOCl2), then treated with ammonia to form the amide.
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4-Nitrobenzamide
The isolated intermediate: a white to pale yellow crystalline powder, ready for catalytic or chemical reduction to the amino derivative.
This product -
Reduction
The nitro group is reduced by catalytic hydrogenation (Pd/C, H2) or chemical methods (Fe/HCl, Sn/HCl, Na2S2O4) to give 4-aminobenzamide (p-aminobenzamide).
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Drug & dye synthesis
4-Aminobenzamide enters sulfonamide drug synthesis (acylation with sulfonyl chlorides), azo dye manufacture (diazotisation and coupling) or agrochemical intermediate production.
Downstream derivatives and applications
Reduce Para Nitrobenzamide and the resulting 4-aminobenzamide opens doors to pharmaceuticals, dyes and agrochemicals. The cards below show the principal derivative families that drive demand for this intermediate.
4-Aminobenzamide
The primary amine formed by reducing the nitro group. A key pharmaceutical intermediate used as a building block for active pharmaceutical ingredients and as a coupling component in dye synthesis.
- CAS
- 2835-68-9
- Route
- Catalytic hydrogenation
- Typical use
- APIs, dyes
Sulfonamide drugs
4-Aminobenzamide is acylated with sulfonyl chlorides to produce sulfonamide antibiotics and related pharmaceutical actives. The amide group provides a handle for further functionalisation of the drug molecule.
- Class
- Antibiotics
- Route
- Acylation of amino group
- Typical use
- Pharmaceuticals
Azo dye intermediates
The amino group of 4-aminobenzamide is diazotised with sodium nitrite in acid and the resulting diazonium salt coupled onto phenols or naphthols to produce azo dyes with good substantivity.
- Route
- Diazotisation
- Shade
- Yellow to orange azo dyes
- Typical use
- Textile, paper dyes
Agrochemical intermediates
Both Para Nitrobenzamide and its amino derivative serve as building blocks in agrochemical synthesis, where the amide and amine functionalities are incorporated into herbicide and fungicide structures.
- Route
- Amide coupling
- Class
- Herbicides, fungicides
- Typical use
- Crop protection
Need the upstream acid? Para Nitrobenzoic Acid is the carboxylic acid precursor to this product. If your process starts one step earlier, or if you run both the acid and the amide, both can come on the same order.
Where Para Nitrobenzamide ends up
Para Nitrobenzamide itself is an intermediate, not a finished product. It reaches you as a building block, and its quality shows up in the yield, purity and performance of the downstream pharmaceutical, dye or agrochemical product.
Pharmaceutical synthesis
The primary route to 4-aminobenzamide, a precursor for sulfonamide antibiotics and other active pharmaceutical ingredients. Pharmaceutical manufacturers need high purity and consistent melting point, both of which trace directly to the quality of the Para Nitrobenzamide charged to the hydrogenation reactor.
Dye and pigment manufacture
Reduced and diazotised, the amino derivative couples onto phenols and naphthols to produce azo dyes for textiles, paper and leather. The amide group improves the substantivity and wash-fastness of the resulting dyestuff.
Agrochemical intermediates
The amide and nitro/amino functionalities are incorporated into herbicide and fungicide structures. Agrochemical formulators require a clean intermediate with minimal isomeric contamination to keep synthesis yields high and impurity profiles within registration limits.
What buyers check before they switch supplier
Four parameters explain most of the yield and purity complaints we hear about when a plant changes its source of Para Nitrobenzamide.
Assay against your charge
Downstream reactions are built on active content. A drop in assay means lower reduction yield, weaker API potency and wider impurity profiles in the final product.
Melting point range
A sharp 199–201 °C range confirms identity and purity. A depressed or broadened range points to isomeric contamination or residual 4-nitrobenzoic acid that will carry through the reduction.
Residue on ignition
Inorganic residues can poison hydrogenation catalysts (Pd/C) and introduce trace metals into pharmaceutical intermediates, triggering ICH Q3D elemental impurity failures.
Related substances
Isomeric nitrobenzamides (2-nitro, 3-nitro) and the hydrolysis product (4-nitrobenzoic acid) reduce yield and complicate purification of the amino derivative downstream.
Tested in-house, documented in full
Consistent intermediate quality does not happen by accident. Each lot of Para Nitrobenzamide is checked against its specification before it leaves, and the result goes out with the material so your goods-in team can release it without a second test.
- Each lot tested against the product specification before dispatch
- Batch test report supplied with every shipment
- Safety Data Sheet supplied with the first order and on request
- Technical and specification sheets available before you order
- Samples sent with their own test data, so a trial compares like with like
- Technical team available to discuss reduction conditions, catalyst compatibility and downstream process fit
What arrives with the material
Enough paperwork for your goods-in and quality teams to release the lot without retesting it.
- Batch test report
- The tested figures for the lot you have received, set against the specification.
- Safety Data Sheet
- Classification, protective equipment, storage conditions, first aid and spill response.
- Specification sheet
- The parameters and limits we supply against, available before you place the order.
- Sample test data
- Sent with every trial sample, so a comparison against your current material starts from the same numbers.
Packing, storage and handling
Para Nitrobenzamide is a stable crystalline solid under normal conditions. Follow all guidance in the Safety Data Sheet for protective equipment and exposure control.
How it ships
- Supplied in moisture-resistant packing, typically HDPE-lined fibre drums or bags
- Bulk quantities can be discussed where your process suits larger packs
- Every pack carries the product name, lot number and hazard information
- Pack size can be matched to your reactor charge to minimise part-used containers
- Shipped with its batch test report and Safety Data Sheet
Storing and handling on site
- Store in a cool, dry place, out of direct sunlight and protected from moisture
- Keep containers closed between charges to prevent moisture uptake and light degradation
- Control dust at all transfer points and avoid breathing it
- Avoid skin and eye contact; wear the protective equipment specified in the SDS
- Keep apart from strong reducing agents and strong oxidisers in storage
- Rotate stock so older lots are used first
Read the Safety Data Sheet before first use. Para Nitrobenzamide carries specific handling precautions. The SDS sets out the required protective equipment, storage conditions, first-aid measures and spill response. If anything on it is unclear, ask our technical team.
How to order Para Nitrobenzamide
Start with a sample, move to scheduled supply. Four steps from first enquiry to a delivery pattern that matches your production plan.
Send your requirement
Product name, grade or specification, quantity, packing and delivery location, through the contact page.
Get the paperwork
We come back with the specification sheet, the Safety Data Sheet and a quote against your quantity and packing.
Run a sample
A sample with its test data, so you can reduce it and compare yield and purity against your current material.
Confirm supply
Once the trial clears, we schedule repeat supply to the same specification, lot after lot.
Para Nitrobenzamide: frequently asked questions
What buyers, chemists and plant teams ask us most about this product. For anything else, get in touch.
What is Para Nitrobenzamide?
Para Nitrobenzamide (4-nitrobenzamide) is the amide of 4-nitrobenzoic acid. It is a white to pale yellow crystalline powder used as a pharmaceutical and dye intermediate. The nitro group at the para position is reduced to an amine to give 4-aminobenzamide, which feeds into sulfonamide drug synthesis and azo dye manufacture.
What is the CAS number and molecular formula?
The CAS number is 619-80-7. The molecular formula is C7H6N2O3 and the molecular weight is 166.13 g/mol. The compound melts at 199–201 °C.
How is Para Nitrobenzamide synthesised?
It is made from benzoic acid in two steps. First, benzoic acid is nitrated with mixed acid to give 4-nitrobenzoic acid. Second, the acid is converted to the acid chloride with thionyl chloride (SOCl2) and then treated with ammonia to form the amide. Alternative routes use direct amidation with ammonium carbonate or urea.
What is 4-aminobenzamide and how is it made from this product?
4-Aminobenzamide (p-aminobenzamide, CAS 2835-68-9) is the reduction product of Para Nitrobenzamide. The nitro group is reduced to an amine by catalytic hydrogenation over Pd/C or by chemical reduction with iron and hydrochloric acid, tin and hydrochloric acid, or sodium dithionite. The amide group remains intact under these conditions.
What are the pharmaceutical uses of Para Nitrobenzamide?
Reduced to 4-aminobenzamide, it serves as a precursor for sulfonamide antibiotics. The amino group is acylated with sulfonyl chlorides to build the sulfonamide pharmacophore. It is also used as an intermediate in the synthesis of other active pharmaceutical ingredients where the benzamide scaffold is part of the target molecule.
How is Para Nitrobenzamide used in dye chemistry?
The reduction product, 4-aminobenzamide, is diazotised with sodium nitrite in dilute acid to form a diazonium salt, which then couples onto phenols, naphthols or other coupling components to produce azo dyes. The amide group on the molecule improves the substantivity and wash-fastness of the resulting dyestuff on textile fibres.
Is Para Nitrobenzamide soluble in water?
Only slightly. It is sparingly soluble in cold water but dissolves in hot ethanol, DMSO and dilute alkali solutions. For reactions that require a homogeneous solution, the material is typically dissolved in DMSO, warm ethanol or dilute sodium hydroxide.
What is the difference between Para Nitrobenzamide and Para Nitroaniline?
Both carry a nitro group at the para position of a benzene ring. Para Nitrobenzamide has a CONH2 (amide) group at position 1, while Para Nitroaniline has an NH2 (amine) group. They lead to different downstream products: the amide to sulfonamide drugs and amide-bearing dyes, the aniline directly to azo dyes via diazotisation.
What purity do you supply?
Standard commercial material is supplied at a minimum assay of 99% by HPLC, with the actual figure for your lot on the batch test report. If you work to a pharmaceutical-grade specification with tighter impurity limits, send it and we will confirm what we can supply.
How does the quality of Para Nitrobenzamide affect downstream products?
Assay sets the active content and therefore the yield of the reduction step. Isomeric impurities (2-nitro, 3-nitro isomers) carry through to contaminate the amino product. Residual 4-nitrobenzoic acid indicates incomplete amidation and wastes reducing agent. Inorganic residues can poison hydrogenation catalysts and introduce trace metals into pharmaceutical intermediates.
What reduction methods work best?
Catalytic hydrogenation over palladium on carbon (Pd/C) in ethanol or ethyl acetate gives clean, high-yield reduction with easy catalyst removal by filtration. Chemical reduction with iron and dilute hydrochloric acid (Béchamp reduction) is a lower-cost alternative for larger-scale operations. Sodium dithionite in aqueous alkaline solution is used where metal contamination must be avoided.
Can the amide group be hydrolysed during reduction?
Under the mild conditions used for nitro-group reduction (low temperature, near-neutral to mildly acidic pH), the amide is hydrolytically stable. Prolonged treatment with strong acid or strong base at elevated temperature can hydrolyse the amide to 4-aminobenzoic acid, so reaction conditions should be controlled to preserve the amide bond.
Is Para Nitrobenzamide used in research?
Yes. It is widely used as an organic synthesis building block in academic and industrial research laboratories. It serves as a model substrate for nitro-group reduction studies, as a precursor for combinatorial chemistry libraries and as a reference standard in analytical method development.
How is Para Nitrobenzamide packed and stored?
It ships as a powder in moisture-resistant packing (HDPE-lined drums or bags), labelled with the product name, lot number and hazard information. Store it in a cool, dry place, out of direct sunlight and protected from moisture. Keep containers closed between uses and use older stock first.
Can I get a sample, and is there a minimum order?
Yes to samples, sent with their test data so a trial compares like with like. Order quantities depend on the packing, so tell us the volume you expect through the contact page and we will confirm what is practical.
Tell us the grade and quantity of Para Nitrobenzamide you need
Send your specification, the quantity and where it ships to, and our technical team will come back with the specification sheet, a quote and a sample plan. If you also buy Para Nitrobenzoic Acid, Para Nitroaniline or other intermediates, put them on the same enquiry.